In the realm of gaming, there are pioneers who push the boundaries of what is possible. And then there's Lauren Ramlan, a bioengineering researcher from MIT, who has taken the phrase "running Doom on everything" to a whole new level. In a mind-boggling display of creativity, Ramlan proposes running Doom through a 1-bit display of bioluminescent E. coli. Yes, you read that right. We're talking about bacteria-powered gaming here.

Now, before you start picturing E. coli with tiny VR headsets and tiny game controllers, let me clarify something. Ramlan's project is not about the E. coli performing the calculations to run Doom. That would be a bit too much to ask from our microscopic friends. Instead, the E. coli are used to create a visual display for the game. Think of it as Doom on a living canvas.

Some strict purists might argue that in order for Doom to truly be "running" on something, it needs to be installed on that something. For example, there's Sick Codes' Doom on a John Deere tractor control module, which is as bizarre as it sounds. But I believe that such rigid definitions only hinder our ability to appreciate the ingenuity behind projects like E. coli Doom, Notepad Doom, or even Ti-84 calculator Doom powered by moldy potatoes (yes, that's a thing). Let's embrace a more postmodern interpretation of what it means to run Doom on anything.

So, how does E. coli Doom work? Well, Ramlan arranges the E. coli cells in a grid pattern to form a 1-bit 32x48 resolution display. By manipulating the activation and deactivation of a fluorescence-blocking gene in the cells, the screen lights up and produces a frame of the game. It's like watching Doom unfold through the glowing dance of bacteria.

Now, here comes the not-so-pleasant part. E. coli Doom is not for the impatient. Each frame of the game takes an excruciatingly long time to generate. Full fluorescence requires a staggering 70 minutes, and resetting the screen for the next frame takes a mind-numbing 8-hour wait. If you thought waiting for your game to load was frustrating, imagine waiting 8 hours just to see the next frame of Doom. Talk about delayed gratification!

Considering these time-consuming processes, you might be wondering how long it would take to actually play Doom in this manner. Well, Ramlan estimates that it would take a whopping 600 years to complete the game. That's right, folks, you heard it here first. If you were to embark on the journey of E. coli Doom today, you'd have to pass the torch to your great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-great-g

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